Figure 3.

Unweighted (left panel) and IP-weighted^a (right panel) cumulative incidence of mortality for patients with receipt of daily and non-daily prescription opioid, 2010-2015.

^aIP-weighted curve was adjusted for baseline covariates: age, sex, US census region, index year, Charlson comorbidity index, substance use disorders (alcohol, smoking, opioid overdose), surgical procedure, fracture and strains, pain conditions (headache, neck and jaw pain, back pain, abdominal pain, fibromyalgia), measured at baseline and index periods, and opioid use disorder diagnosis, psychiatric medications (benzodiazepines, antidepressants, gabapentin), number of opioid providers and average daily prescription opioid dose during the index period.