Figure 1. Association analyses within the chr12q24.13 region in relation to COVID-19 outcomes in patients of European ancestry.

a) Association analyses in 601 patients with non-hospitalized (mild) compared to 954 patients with hospitalized COVID-19. b) Variants included in SuSie 95% credible sets and their posterior inclusion probabilities (PIP); two 95% credible sets were identified with a threshold of an average correlation between all variables >0.9. c) Association analyses in 601 patients with non-hospitalized (mild) compared to 566 patients with hospitalized severe COVID-19. d) LD plot (r²) in the total set of 1555 patients with COVID-19 and location of OAS1, OAS3, and OAS2 reference transcripts. Blue shading indicates the 32Kb LD block (hg38: chr12:112912991-112945172) that includes 135 variants in r²>0.8 with the lead rs10774671; 125 of these variants form only two common haplotypes – risk and non-risk. The Neandertal-introgressed genomic fragment of 97 Kb is marked based on previously reported variants⁷. e) Analysis of haplotypes including four core variants tagging the Neandertal haplotype and extended haplotypes additionally including three variants associated with severe COVID-19. Full association results for individual variants and haplotypes are provided in Table S1.