Figure 3. Allelic expression imbalance of OAS1 transcripts.

a) Outline of allelic imbalance analysis for transcribed OAS1 variants based on RNA-seq reads. Counts of allele-specific RNA-seq reads in heterozygous samples for transcribed OAS1 variants rs1131454 and rs2660 in b) nasal epithelial cells – uninfected (Mock) and infected with Rhinovirus (RV) strain A or C or c) in PBMCs from patients with COVID-19 and healthy controls (labeled as non-COVID). d) Haplotypes of the three OAS1 variants used for analysis. e) Haplotype-specific imbalance in OAS1 expression contributed by rs1131454. P-values are for non-parametric, Wilcoxon matched pairs signed-rank tests.