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. 2021 Jan 25;8(6):nwab013. doi: 10.1093/nsr/nwab013

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© The Author(s) 2021. Published by Oxford University Press on behalf of China Science Publishing & Media Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — Detecting protein aggregation using AIEgens. (a) The multistep process of protein aggregation. (b) Examples of TPE-based AIEgens to detect protein aggregation. TPE-MI: tetraphenylethene maleimide. BSPOTPE: 1,2-bis[4-(3-sulfonatopropoxyl)phenyl]-1,2-diphenylethene salt. TPE-TPP: bis(triphenylphosphonium) tetraphenylethene. (c) a-synuclein aggregation monitored by TPE-TPP. (d) Structure of AggFluor probes. (e) Converting ACQ probes to AIEgens. (f) Ratiometric imaging of protein aggregation using NTPAN-MI. (d) was modified from Wolstenholme et al. [8]; (f) was modified from Owyong et al. [10].