TABLE 2.

Summary of potential uses of multiplex pathogen panels for the diagnosis of viral gastroenteritis

Clinical scenario	Potential utility of multiplex pathogen testing
Uncomplicated inpatient with watery diarrhea	Currently available evidence does not support routine use of syndromic testing
Hematologic stem cell transplant recipients	Positive identification of viral pathogen (i.e., norovirus) could prompt reduction in immunosuppression; conversely, a negative result may increase likelihood of alternate noninfectious etiologies (i.e., graft-vs-host disease)
Solid organ transplant recipients	Negative results may accelerate timeline to advanced diagnostic techniques (i.e., colonoscopy) and consideration of alternate noninfectious etiologies (i.e., mycophenylate toxicity)
Advanced HIV disease	Negative results may accelerate timeline to advanced diagnostic techniques (i.e., colonoscopy)
Epidemic response	Rapid identification of an alternate diagnosis can decrease suspicion for a novel/severe pathogen (i.e., SARS-Cov-2, Ebola)