Table 1.

Summary of nanomaterials for treatment of hypoxic tumor.

Strategies	Nanomaterials for treatment of hypoxic tumor	Examples	Key references
Elevating oxygen level in tumor	Oxygen-carrying nanomaterials	Oxygen nanobubbles Hb-containing oxygen-carrying nanomaterials	[35–40] [45–54]
		PFC-containing oxygen-carrying nanomaterials	[59–67]
	Oxygen-generating nanomaterials	H2O2-based oxygen-generating nanomaterials	[69–75,84–87,89–91,95–102]
		H2O-based oxygen-generating nanomaterials	[103–106]
	Oxygen-economizing nanomaterials	Respiration-inhibiting oxygen-economizing nanomaterials	[109–112,114–116]
Diminishing oxygen dependence	Therapeutic gas-generating nanomaterials	NO-generating nanomaterials·OH-generating nanomaterials	[126,127][138–143]
	Radical-generating nanomaterials	·R-generating nanomaterials	[146–148]