Figure 1.

Schematic. (a) The six degenerate bases. (b) Schematic of error-correction code (ECC) sequencing. The ideal sequencing signals, or the lengths of the consecutive identical degenerate bases, is called the ‘degenerate polymer length’ (DPL). (c) The phenomenon that the nascent DNA strands progressively lose their synchronicity, also called ‘dephasing,’ is common in sequencing-by-synthesis-based DNA sequencing technologies. (d) Illustration of ‘one-base slippage’ (OBS) scheme. (e) Chemical reactions simulated in the virtual sequencer.