Table 3.
Relationship of CSF biomarkers and cognitive domains among people with HIV
| MCP-1 | IP-10 | |||
|---|---|---|---|---|
| Cognitive Domain | beta (SE) | p-value1 | beta (SE) | p-value1 |
| Verbal Fluency | −2.1 (2.6) | ns | −1.2 (1.3) | ns |
| Executive Function | −2.4 (2.8) | ns | −1.2 (1.5) | ns |
| Attention/Working Memory | −3.8 (2.6) | ns | 0.1 (1.3) | ns |
| Processing Speed | −3.1 (2.7) | ns | −0.3 (1.4) | ns |
| Learning | −6.3 (2.6) | 0.016 | −2.3 (1.4) | 0.036 |
| Delayed Recall/Memory | −3.9 (2.6) | ns | −1.9 (1.4) | ns |
| Motor | −2.3 (3.0) | ns | −0.2 (1.6) | ns |
Cognitive T-scores are adjusted for age, sex/gender, race, and years of formal education, and models adjust for current tobacco use and current CD4+ T cell count
1
p-values were adjusted using false discovery rate (FDR) correction for multiple comparisons
Abbreviations: ns = non-significant (p ≥ 0.05); CSF = cerebrospinal fluid; HIV = human immunodeficiency virus; MCP-1 = monocyte chemoattractant protein-1; IP-10 = interferon-gamma-inducible protein-10