Table2.
Combination index analysis of microRNA-101 and etoposide in A549 cells
| Etoposide concentration (µM) | 24 hours | 48 hours | ||||
|---|---|---|---|---|---|---|
| Fa | CI | Combined effect | Fa | CI | Combined effect | |
| 0.25 | 0.23 | 0.93 | S | 0.30 | 0.90 | S |
| 0.5 | 0.36 | 0.87 | S | 0.43 | 0.84 | S |
| 1 | 0.68 | 0.85 | S | 0.78 | 0.71 | S |
| 2 | 0.82 | 0.83 | S | 0.94 | 0.79 | S |
| 4 | 0.92 | 0.80 | S | 0.99 | 0.77 | S |
| 8 | 0.99 | 0.78 | S | 1 | 0.74 | S |
| 16 | 1 | 0.76 | S | 1 | 0.72 | S |
The Chou-Talalay drug combination index (CI) method was used to determine the synergy (S), additivity, or antagonism of the microRNA-101/etoposide combinations. The synergy, additivity, and antagonism were indicated with CI <1, =, or >1. Fa: Fraction affected