Table 2:

Factors predisposing to rapid progression in children born to second generation HIV mother-to-child transmission

1	Mothers are often slow progressors, surviving many years without cART, so may not realise the life-saving importance of cART
2	The transmitted virus may have accumulated HIV drug resistance
3	The transmitted virus may have adapted to HLA class I alleles shared by the mother and child
4	Pregnancy often occurs during adolescence, a developmental stage notorious for poor cART adherence
5	The psychological effects of late disclosure can result in poor cART adherence and onward disclosure
6	Long-standing maternal HIV-infection results in poor maternal health