Table 1. – Baseline characteristics of patients in each quartile of plasma NT-proBNP levels.
| Characteristics | All patients included | NT-proBNP (pg/mL) | p value | |||
|---|---|---|---|---|---|---|
|
| ||||||
| <124 | 124-271 | 271-668 | ≥668 | |||
| n | 724 | 181 | 180 | 182 | 181 | |
| Age(years) | 86.6±3.0 | 85.7±2.9 | 86.1±2.9 | 87.0±2.9 | 87.4±3.0 | <0.001 |
| Male(%) | 680(93.9) | 171(94.5) | 169(93.9) | 168(92.3) | 172(95.0) | 0.727 |
| Female(%) | 44(6.1) | 10(5.5) | 11(6.1) | 14(7.7) | 9(5.0) | |
| CHD(%) | 589(81.4) | 135(74.6) | 144(80) | 150(82.4) | 160(88.4) | 0.008 |
| HT(%) | 544(75.1) | 124(68.5) | 135(75) | 144(79.1) | 141(77.9) | 0.088 |
| DM(%) | 298(41.2) | 71(39.2) | 69(38.3) | 76(41.8) | 82(45.3) | 0.537 |
| AF(%) | 130(18.0) | 15(8.3) | 16(8.9) | 27(14.8) | 72(39.8) | <0.001 |
| BMI(kg/m2) | 23.8±2.6 | 24.7±2.3 | 23.7±2.3 | 23.5±2.7 | 23.3±2.9 | <0.001 |
| NT-proBNP(pg/mL) | 770±818 | 70±27 | 190±37 | 420±93 | 2399±1618 | <0.001 |
| eGFR(ml/min.1.73m2) | 75.7±20.4 | 82.8±17.2 | 77.8±19.7 | 75.6±20.7 | 66.6±22.1 | <0.001 |
| sCr(ug/mL) | 99.6±29.4 | 85.1±16.6 | 92.4±21.2 | 98.1±28.3 | 122.5±50.3 | <0.001 |
| BUN(mmol/L) | 7.61±2.50 | 6.48±1.63 | 6.83±1.64 | 7.59±2.41 | 9.55±3.88 | <0.001 |
| TC(mmol/L) | 4.14±0.67 | 4.31±0.67 | 4.24±0.65 | 4.00±0.69 | 3.99±0.61 | <0.001 |
| TG(mmol/L) | 1.45±0.57 | 1.62±0.60 | 1.41±0.54 | 1.42±0.62 | 1.34±0.50 | 0.023 |
| LDL-C(mmol/L) | 2.37±0.57 | 2.54±0.59 | 2.46±0.57 | 2.23±0.57 | 2.26±0.52 | <0.001 |
| HDL-C(mmol/L) | 1.16±0.23 | 1.13±0.24 | 1.18±0.25 | 1.18±0.27 | 1.16±0.29 | 0.473 |
| Hb(g/L) | 124.6±13.9 | 131.6±12.5 | 125.3±11.8 | 122.1±13.6 | 119.2±15.4 | <0.001 |
| ALB(g/L) | 39±2.8 | 40.0±2.6 | 39.8±2.7 | 38.4±2.7 | 37.7±2.8 | <0.001 |
| LVEF(%) | 60.0±3.8 | 61.4±3.1 | 60.8±2.9 | 59.7±4.2 | 57.9±4.4 | <0.001 |
| LVEF<40% | 3 | 0 | 0 | 1 | 2 | |
| LVEF>50% | 697 | 180 | 179 | 173 | 165 | |
| LVEDD(mm) | 48.5±2.8 | 48.2±2.5 | 47.9±2.3 | 48.8±2.7 | 49.3±3.4 | 0.002 |
| LVESD(mm) | 32.9±2.3 | 32.2±1.7 | 32.3±2.0 | 33.2±2.4 | 34.0±2.9 | <0.001 |
| LAD(mm) | 37.2±3.1 | 36.3±2.7 | 36.0±2.8 | 37.4±2.6 | 39.3±3.9 | <0.001 |
| IVS(mm) | 10.7±1.1 | 10.6±1.0 | 10.5±1.0 | 10.7±1.2 | 10.9±1.2 | 0.040 |
| PLVW(mm) | 10.1±0.7 | 10.0±0.6 | 10.0±0.6 | 10.2±0.8 | 10.2±0.9 | 0.203 |
| LVMI(g/m2) | 123.2±19.9 | 118.9±15.7 | 118.0±16.0 | 126.7±19.4 | 129.1±27.5 | <0.001 |
| Anti-platelet drugs(%) | 493(68.1) | 118(65.2) | 129(71.7) | 120(65.9) | 126(69.6) | 0.506 |
| Statins(%) | 311(43.0) | 84(46.4) | 70(38.9) | 78(42.9) | 79(43.6) | 0.547 |
| CCB(%) | 361(49.9) | 95(52.5) | 93(51.7) | 87(47.8) | 86(47.5) | 0.697 |
| ACEI(%) | 92(12.7) | 21(11.6) | 25(13.9) | 14(7.7) | 32(17.7) | 0.035 |
| ARB(%) | 227(31.4) | 55(30.4) | 62(34.4) | 68(37.4) | 42(23.2) | 0.023 |
| ACEI/ARB(%) | 307(42.4) | 72(39.8) | 85(47.2) | 79(43.4) | 71(39.2) | 0.386 |
| Betablocker(%) | 291(40.2) | 58(32.0) | 56(31.1) | 82(45.1) | 95(52.5) | <0.001 |
| Mean SBP(mmHg) | 129.3±9.4 | 129.3±9.4 | 129.9±8.5 | 128.6±9.4 | 129.4±10.2 | 0.753 |
| Mean DBP(mmHg) | 67.3±5.8 | 68.2±5.7 | 68.1±5.2 | 66.9±5.9 | 66.2±6.1 | 0.027 |
| MBP(mmHg) | 88.0±6.0 | 88.6±6.2 | 88.7±5.2 | 87.5±5.9 | 87.3±6.4 | 0.152 |
| PP(mmHg) | 61.9±8.6 | 61.1±7.9 | 61.9±8.7 | 61.7±8.6 | 63.2±9.2 | 0.348 |
CHD: coronary heart disease; HT: hypertension; DM: diabetes mellitus; AF: atrial fibrillation; BMI: body mass index; NT-proBNP: N-terminal pro-brain natriuretic peptide; eGFR: estimated glomerular filtration rate; sCr: serum creatinine; BUN: blood urea nitrogen; UA: uric acid; TC: total cholesterols; TG: triglycerides; LDL-C: low density lipoprotein-cholesterol; HDL-C: high density lipoprotein-cholesterol; Hb: hemoglobin; ALB: plasma albumin; LVEF: left ventricular ejection fraction; LVEDD: left ventricular end-diastolic diameter; LVESD: left ventricular end-systolic diameter; LAD: left atrial diameter; IVS: interventricular septum; PLVM: posterior left ventricular wall; LVMI: left ventricular mass index; CCB: calcium channel blocker; ACEI: angiotensin converting enzyme inhibitor; ARB: angiotensin receptor antagonists; SBP: systolic blood pressure; DBP: diastolic blood pressure; MBP: mean blood pressure; PP: pulse pressure.