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Effect of megalin KO on ENaC and NHE3 in the kidney with podocyte injury. Compared to NEP25/megalin control (Cont) mice, NEP25/megalin KO mice showed fewer cleaved α and γ subunits of ENaC and NHE3 (A, C, D). There was no significant difference in the β subunit of ENaC (B) and pNHE3 (E). Bars represent the means ± 95% confidence intervals.
