Table 3.

Cox proportional hazard model to estimate hazard ratios and 95% CI for time to first therapy and OS in MBL and Rai 0 CLL

CLL-IPI risk group	MBL
	Time to first therapy			Overall survival
	HR	95% CI	P	HR	95% CI	P
Intermediate vs low	2.7	1.6-4.5	.0002	1.9	1.1-3.1	.01
High vs low	6.2	3.1-12.5	<.0001	2.6	1.4-5.1	.003
Very high vs low	Not estimable	—	—	5.3	1.3-22.0	.02
CLL-IPI risk group	CLL
	Time to first therapy			Overall survival
	HR	95% CI	P	HR	95% CI	P
Intermediate vs low	2.9	2.1-4.0	<.0001	2.0	1.4-3.0	.0005
High vs low	6.1	3.7-9.5	<.0001	4.2	2.5-7.2	<.0001
Very high vs low	5.4	1.8-15.0	.002	12.2	5.9-25.1	<.001

Values in bold indicate P < .05.