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. 2021 Feb 17;138(2):178–189. doi: 10.1182/blood.2020009345

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© 2021 by The American Society of Hematology

This article is made available via the PMC Open Access Subset for unrestricted reuse and analyses in any form or by any means with acknowledgment of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections.

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Figure 4. — Effects of 5C12 anti-FXII antibody treatment on blood cell counts, leukocyte accumulation in tissues, and neutrophil activation markers in baboons following lethal challenge with HI-SA (LDSA). (A-F) Time course dynamics of RBCs (A), hematocrit (B), white blood cells (WBCs) (C), polymorphonuclear neutrophils (PMNs) (D), lymphocytes (E), and monocytes (F) in animals infused with LDSA only or infused with LDSA and treated with 5C12 (LDSA + 5C12). (G) Immunofluorescence staining for neutrophil elastase (left), and CD68 (middle) as markers for neutrophils and monocytes/macrophages, respectively, in lungs of baboons challenged with LDSA, without (top) or with 5C12 treatment (LDSA + 5C12; bottom). Merged color images are shown in the right panels. Nuclei were stained with To-PRO-3 (blue). Scale bars, 100 µm. Confocal images were captured by using a Nikon Eclipse TE2000-U microscope equipped with a Nikon C1 scanning head; the Nikon EZ-C1 software (version 3.80) was used for image acquisition. (H) Time course changes of MPO activity in plasma. Same time points are compared between the treated and untreated baboons by using the generalized least squares (gls) function. *P < .05; **P < .01; ***P < .001. The overall P value (pvl) describing the difference between the 2 curves is shown on each graph. P < .05 is considered significant.