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. 2021 Feb 17;138(2):178–189. doi: 10.1182/blood.2020009345

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© 2021 by The American Society of Hematology

This article is made available via the PMC Open Access Subset for unrestricted reuse and analyses in any form or by any means with acknowledgment of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections.

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Figure 5. — Effects of 5C12 anti-FXII antibody treatment on renal, hepatic, and pancreatic damage and function parameters in baboons infused with a lethal dose of HI-SA (LDSA). Time course changes of plasma levels of kidney function biomarkers: blood urea nitrogen (BUN) (A), and creatinine (B), liver injury biomarker alanine aminotransferase (ALT) (C), pancreas injury biomarker amylase (D), and glucose regulation (E). Same time points are compared between the control baboons (LDSA) and the 5C12-treated animals (LDSA + 5C12) using the generalized least squares (gls) function. *P < .05; **P < .01; ***P < .001. The overall P value (pvl) describing the difference between the 2 curves is shown on each graph. P < .05 is considered significant.