Table 4.

Individual aGVHD organ staging and overall aGVHD grade at time of diagnosis

Patient no.	GVHD onset day+	PANO % dose prior to GVHD onset	Skin stage	Gut stage	Liver stage	Overall grade	GVHD treatment with systemic steroids? (> 1 mg/kg)
1*	41	100	1	1	0	II	Yes
2	53	100	2	1	0	II	Yes
3	27	30†	2	1	0	II	Yes
4	22	100	0	1	0	II	No‡
5§	66	97	0	1	0	II	No
6ǁ	18	100	0	1	0	II	No
7¶	38	45#	0	3	0	III	Yes

^*Noncompliance with immunosuppression prior to GVHD.

^†PANO held due to rash prior to GVHD.

^‡GVHD resolved with TAC/SIR levels adjustment.

^§Upper gastrointestinal symptoms suspected due to narcotic withdraw with upper gastrointestinal histology GVHD grade 1. Nausea resolved with supportive care.

^ǁSuspected delayed chemotherapy toxicity with upper gastrointestinal histology grade 1 GVHD. Symptoms resolved with supportive care.

^¶Ruxolitinib discontinued within 30 days before HCT and GVHD resolution with steroids and ruxolitinib after HCT.

#PANO held due to AEs (confusion/prolonged QT corrected for heart rate/pneumonia).