Skip to main content
. Author manuscript; available in PMC: 2021 Jul 19.
Published in final edited form as: Nat Rev Cancer. 2021 May 5;21(7):446–460. doi: 10.1038/s41568-021-00353-1

Fig. 3 ∣. Long noncoding RNAs regulate metastasis via various pathways using diverse mechanisms.

Fig. 3 ∣

Shown are long noncoding RNAs (lncRNAs) with their associated pathways (left) and the biological processes in metastasis that they regulate (right) linked by lines to show lncRNAs interacting with specific pathways to regulate certain biological processes. LncRNAs are grouped from left to right by their downstream mechanism shown on the top panel. For each downstream mechanism, an example detailed mechanism of a lncRNA is presented. LncRNAs in grey boxes are those for which consensus pathway involvement has not been characterized. An asterisk (*) indicates lncRNAs that are involved in multiple pathways or that regulate multiple biological processes in metastasis. In the top panel downstream mechanisms are shown by which representative lncRNAs regulate epithelial–mesenchymal transition (EMT). NF-κB, nuclear factor-κB.