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. Author manuscript; available in PMC: 2021 Jul 19.
Published in final edited form as: Nat Rev Cancer. 2021 May 5;21(7):446–460. doi: 10.1038/s41568-021-00353-1

Fig. 6 ∣. Long noncoding RNAs and tumour microenvironment.

Fig. 6 ∣

a ∣ NKILA inactivates the nuclear factor-κB (NF-κB) pathway in breast cancer cells, and NKILA downregulation leads to decreased metastatic potential. In tumour-infiltrating T lymphocytes, NKILA leads to sensitization to activation-induced ceLL death. b ∣ CamK-A activates NF-κB in response to microenvironmental hypoxia, leading to activation of IL-6/IL-8 and VEGF, which increase macrophage recruitment and angiogenesis. c ∣ LNMAT1 activates CCL2 and CCL2-dependent macrophage recruitment in bladder cancer metastasis. hnRNPL, heterogeneous nuclear ribonucleoprotein L.