Table 2.
Stool related indices in Stage 2 (Dosed patients, n = 34).
| Baseline (mean, SD) | Fixed dose (mean, SD) | p-Value | |
|---|---|---|---|
| CSBMa | 1.2 (0.90) | 3.6 (2.35) | 1.2 × 10−7 |
| SBMa | 2.6 (1.45) | 4.4 (2.16) | 1.2 × 10−5 |
| Suppository usea | 1.8 (1.92) | 0.3 (0.67) | 2.3 × 10−5 |
| Consistencyc | 2.7 (1.20) | 4.1 (2.15) | 0.0002 |
| Ease of passageb | 3.2 (0.73) | 3.7 (1.19) | 0.04 |
| PAC-QOL total | 1.4 (0.49) | 1.2 (0.59) | 0.01 |
| PAC-SYM | 1.3 (0.45) | 1.1 (0.49) | 0.05 |
a
Weekly average.
b
Ease of evacuation scale, where 1-manual disimpaction and 7 = incontinent.
c
Bristol stool scale 1–7, where 1 = separate hard lumps and 7 = liquid consistency.