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. 2021 Jul 19;16(7):e0254116. doi: 10.1371/journal.pone.0254116

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© 2021 Hoffman et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 1 — A. Comparison of treatment for all patients over 3 time points for the metabolites Time A at 6-12hours, Time B at 2 weeks and Time C at 3 months between all patients for tryptophan, kyunrenine, quinolinic Acid (QA), kynurenic acid (KA), 3-OH-anthranilic acid, anthranilic acid, picolinic acid, xanthurenic acid, nicotinamide adenine dinucleotide (NAD), 1-methylnicotinamide and nicotinic Acid. B. Flow diagram of tryptophan/kynurenine pathway. Pathway displaying the percent change differences between Time A divided by Time B and Time A divided by Time C. Red indicates a decrease while green indicates an increase. Major enzymes and cofactors in the Trp/KP: indoleamine 2,3-dioxygenase (IDO); tryptophan-2,3-dioxygenase (TDO); kynurenine aminotransferase (KAT); and kynurenine 3-monooxygenase (KMO); L-kynureninas A and B (KYNU A and KYNU B); vitamin B6; and vitamin B2.