Table 1. Tryptophan/Kynurenine pathway metabolite concentrations in T1D patients.
| Patient | Trp | Kyn | KA | AA | XA | PA | QA | 3OHAA | mg/dL | mEq/L | mg/mL | Age | Disease | Gender | Race | Diastolic |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| uM | nM | nM | nM | nM | nM | nM | Peak Area | Glucose | CO2 | BUN | years | Duration | Abnormal | |||
| 1A | 39.4 | 307.5 | 862.8 | 186.3 | 639.3 | 1209.0 | 667.8 | 9.57E+05 | 595 | <5 | 26 | 13.25 | 1d | M | C | N |
| 1C | 66.3 | 1173.6 | 1299.8 | 283.3 | 711.3 | 1183.4 | 724.2 | 6.31E+05 | ||||||||
| 2A | 41.5 | 411.1 | 530.2 | 294.6 | 370.3 | 890.0 | 510.0 | 6.14E+05 | 416 | <5 | 22 | 14.42 | 5y | F | AA | Y |
| 2B | 51.4 | 633.6 | 466.1 | 128.2 | 432.4 | 831.8 | 618.8 | 1.52E+05 | ||||||||
| 2C | 45.2 | 362.8 | 626.9 | 172.6 | 390.3 | 1087.2 | 571.8 | 2.03E+05 | ||||||||
| 3A | 52.7 | 429.5 | 530.4 | 327.4 | 430.3 | 1402.4 | 516.7 | 8.43E+05 | 338 | 5 | 18 | 13.58 | 9y | F | C | Y |
| 3B | 94.3 | 713.6 | 658.0 | 279.9 | 782.3 | 1349.3 | 553.5 | 3.46E+05 | ||||||||
| 3C | 56.3 | 793.7 | 461.8 | 264.1 | 447.8 | 1102.2 | 649.6 | 2.94E+05 | ||||||||
| 4A | 44.0 | 737.0 | 671.3 | 296.0 | 386.6 | 1139.6 | 450.2 | 3.33E+05 | 441 | 7 | 20 | 16.92 | 3y | M | AA | Y |
| 4B | 67.0 | 1091.5 | 735.0 | 266.1 | 537.2 | 1697.8 | 646.7 | 2.22E+05 | ||||||||
| 4C | 41.8 | 750.7 | 788.1 | 242.8 | 329.9 | 1272.0 | 543.2 | 2.37E+05 | ||||||||
| 5A | 41.1 | 203.7 | 555.0 | 223.9 | 351.6 | 900.5 | 526.7 | 9.12E+05 | 299 | 5 | 14 | 11.42 | 3y | M | AA | N |
| 5B | 56.1 | 365.6 | 582.9 | 271.5 | 452.7 | 1316.7 | 454.0 | 4.84E+05 | ||||||||
| 5C | 46.7 | 438.2 | 506.8 | 269.3 | 354.2 | 811.6 | 475.2 | 3.21E+05 | ||||||||
| 6A | 44.3 | 516.1 | 986.9 | 325.4 | 388.3 | 983.0 | 473.1 | 1.01E+06 | 845 | 7 | 42 | 10.08 | 1d | F | C | N |
| 6B | 52.3 | 702.5 | 626.4 | 188.9 | 424.0 | 926.7 | 513.4 | 2.65E+05 | ||||||||
| 6C | 69.9 | 459.6 | 889.7 | 303.9 | 601.9 | 1263.3 | 435.9 | 5.11E+05 | ||||||||
| 7A | 60.2 | 454.5 | 563.2 | 146.0 | 564.0 | 898.6 | 549.8 | 4.83E+05 | 479 | 7 | 25 | 16.92 | 1y | M | AA | N |
| 7B | 50.7 | 543.0 | 553.1 | 286.8 | 441.9 | 837.9 | 645.4 | 6.38E+05 | ||||||||
| 7C | 45.2 | 408.9 | 629.5 | 229.0 | 374.5 | 661.7 | 511.8 | 2.44E+05 | ||||||||
| 8A | 28.3 | 258.9 | 467.4 | 177.9 | 238.8 | 677.4 | 476.4 | 2.06E+05 | 322 | 11 | 15 | 16.33 | 1d | F | AA | Y |
| 8B | 36.8 | 315.3 | 440.8 | 127.1 | 316.3 | 795.7 | 537.5 | 2.12E+05 | ||||||||
| 8C | 34.9 | 313.2 | 585.2 | 97.0 | 296.2 | 842.3 | 553.5 | 1.77E+05 | ||||||||
| 9A | 25.5 | 295.0 | 376.0 | 141.8 | 210.2 | 516.9 | 365.9 | 2.70E+05 | 541 | 7 | 18 | 13.08 | 1d | M | C | N |
| 9B | 36.2 | 291.4 | 298.7 | 103.3 | 286.4 | 434.1 | 465.6 | 1.12E+05 | ||||||||
| 9C | 37.0 | 226.6 | 888.6 | 164.6 | 361.7 | 998.3 | 388.0 | 6.87E+05 | ||||||||
| 10A | 25.3 | 379.3 | 549.1 | 148.9 | 249.5 | 759.2 | 388.2 | 5.36E+05 | 552 | <5 | 15 | 14.33 | 12y | F | AA | Y |
| 10B | 36.2 | 280.1 | 562.5 | 218.7 | 271.3 | 702.6 | 359.9 | 2.27E+05 | ||||||||
| 10C | 31.9 | 682.9 | 452.2 | 179.9 | 250.9 | 856.7 | 469.0 | 2.93E+05 | ||||||||
| 11A | 19.3 | 185.8 | 308.0 | 153.8 | 207.7 | 470.6 | 434.1 | 2.32E+05 | 576 | 6 | 14 | 11.58 | 1d | F | AA | Y |
| 11B | 31.0 | 314.1 | 413.4 | 169.4 | 243.9 | 969.9 | 336.9 | 3.85E+05 | ||||||||
| 11C | 34.7 | 305.8 | 401.4 | 93.3 | 254.7 | 829.6 | 494.0 | 3.09E+05 | ||||||||
| 12A | 31.2 | 918.2 | 815.3 | 177.4 | 350.0 | 1222.4 | 372.9 | 5.97E+05 | 260 | 7 | 31 | 16.25 | 6y | M | AA | Y |
| 12B | 48.4 | 367.6 | 445.2 | 59.6 | 414.4 | 1014.0 | 487.7 | 5.88E+05 | ||||||||
| 12C | 38.3 | 356.1 | 535.1 | 98.4 | 338.3 | 924.5 | 446.2 | 7.00E+05 | ||||||||
| 13B | 32.7 | 365.1 | 470.1 | 130.4 | 274.6 | 868.2 | 430.7 | 4.82E+05 | 458 | <5 | 12 | 15.25 | 7y | F | C | N |
| 13C | 34.2 | 395.8 | 300.6 | 158.1 | 262.8 | 875.3 | 379.6 | 4.10E+05 | ||||||||
| 14A | 36.2 | 430.8 | 262.2 | 105.5 | 262.2 | 562.9 | 449.4 | 1.15E+05 | ||||||||
| 14B | 29.3 | 296.8 | 475.9 | 203.1 | 227.2 | 1057.5 | 366.4 | 4.00E+05 | 550 | 6 | 22 | 9.67 | 1d | F | AA | N |
| 14C | 29.0 | 258.9 | 362.1 | 128.6 | 233.9 | 955.8 | 405.1 | 2.84E+05 | ||||||||
| 15A | 23.9 | 412.7 | 505.4 | 164.3 | 237.3 | 676.1 | 349.3 | 4.31E+05 | 560 | 6 | 18 | 15.5 | 13y | F | AA | Y |
| 15B | 32.1 | 288.8 | 404.3 | 127.8 | 268.0 | 745.5 | 480.4 | 2.42E+05 | ||||||||
| 15C | 36.3 | 361.7 | 448.1 | 139.4 | 290.8 | 631.7 | 369.2 | 5.11E+05 |
Concentrations of tryptophan/kynurenine pathway metabolites tryptophan (Trp), kynurenine (Kyn), quinolinic acid (QA), kynurenic acid (KA), 3-OH-anthranilic acid (3OHAA), anthranilic acid (AA), picolinic acid (PA), xanthurenic acid (XA) in 15 patients at three time points, Time A at 6-12hours, Time B at 2 weeks and Time C at 3 months after the beginning of treatment. The patient glucose levels, urea nitrogen (BUN), CO2 concentration, age, disease duration, gender, race (African American = AA and Caucasian = C) and diastolic abnormality is also listed.