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. 2021 Jul 19;16(7):e0254186. doi: 10.1371/journal.pone.0254186

Table 2. Factors associated with neovascularization in the fellow eye of patients presenting with unilateral type 3 neovascularization.

Risk factors Fellow eye NV(+) n = 49 Fellow eye NV(-) n = 44 p-value
Age, years 76.9 ± 5.5 77.6 ± 6.5 0.606
Sex, male (%) 9 (18.4%) 9 (20.5%) 0.799*
Follow-up duration, months 68.4 ± 31.4 63.5 ± 31.0 0.458
Diabetes mellitus, no.(%) 12 (24.5%) 4 (9.1%) 0.091
Hypertension, no.(%) 19 (38.8%) 13 (30.0%) 0.350*
Large soft drusen of the fellow eye, no. (%) 41 (83.7%) 16 (36.46%) <0.001*
 Reticular pseudodrusen of the fellow eye, no. (%) 33 (67.3%) 18 (40.9%) 0.017*
Subfoveal choroidal thickness of the fellow eye, μm 156.9 ± 53.4 167.9 ± 78.3 0.176
Choroidal vascular index of the fellow eye, % 60.7 ± 2.0 61.7 ± 2.5 0.047
Type 3 neovascularization stage, no. (%) 0.980*
 1 11 (22.4%) 10 (22.7%)
 2 17 (34.7%) 16 (36.4%)
 3 21 (42.9%) 18 (40.9%)

All continuous data are presented as means ± standard deviations.

p-value by independent t-test,

* p-value by chi-square test,

p-value by Fisher’s exact test,

NV, neovascularization.