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. 2020 Jan 17;7(4):723–736. doi: 10.1093/nsr/nwz201

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© The Author(s) 2020. Published by Oxford University Press on behalf of China Science Publishing & Media Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — (A) Schematic illustration of EMM nanocomposites effectively accumulated at a tumor site under magnetic targeting for T₂-weighted MR imaging. (B) The T₂-weighted image, map and (C) the transverse relaxivity r₂ of EMMs. (D) The in vivo T₂-weighted images and (E) normalized T₂ signal change of 4T1 tumor-bearing mice after intravenous injection of MM nanocomposites in the absence and presence of magnetic targeting. (F) The fluorescence images of 4T1 tumor-bearing mice after intravenous injection of DiR-loaded MMs (MM^DiR) at 1, 2, 4, 10 and 24 h. (G) Fluorescence images and (H) quantitative results of DiR fluorescence intensity in major organs and tumor.