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. 2021 Feb 4;296:100376. doi: 10.1016/j.jbc.2021.100376

Figure 10.

Figure 10

Lnc-ORA contributes to myogenesis by competitively binding IGF2BP2.A, Western blotting identified IGF2BP2 bound with lnc-ORA. B, RIP assay revealed that IGF2BP2 was bound with lnc-ORA (n = 3). C, lnc-ORA RNA stability assays in C2C12 myoblasts (n = 3). D, expression level of miR-532-3p when IGF2BP2 was overexpressed (n = 3). E and F, MyoD and MyHC RNA stability assays in C2C12 cells (n = 3). Data represent the mean ± SD. ∗p < 0.05; ∗∗p < 0.01. IGF2BP2, insulin-like growth factor 2 mRNA-binding protein 2; lnc, long noncoding; lnc-ORA, obesity-related lncRNA; MyHC, myosin heavy chain; MyoD, myogenic differentiation 1; RIP, RNA immunoprecipitation.