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Molecular regulatory mechanism of lnc-ORA that inhibits skeletal muscle myogenesis and induces muscle atrophy. Lnc-ORA controls PTEN protein levels and further activates the PI3K/AKT signaling pathway by functioning as ceRNA to sponge miR-532-3p and interact with IGF2BP2. AKT, protein kinase B; ceRNA, competing endogenous RNA; IGF2BP2, insulin-like growth factor 2 mRNA-binding protein 2; lnc, long noncoding; lnc-ORA, obesity-related lncRNA; PTEN, phosphatase and tensin homolog.
