Table 3.
Potential TB therapeutic compounds targeting host cell recycling and death responses
|
Drug name |
Drug class |
Response affected (pos/neg response) |
Reference |
|---|---|---|---|
|
Levofloxacin |
Fluoroquinolone antibiotic |
Apoptosis (+) |
[200] |
|
Rapamycin |
Macrolide antibiotic |
Apoptosis (+) |
[201] |
|
Carbamazepine |
Anti-convulsant |
Autophagy (+) |
[174] |
|
Isoniazid |
Antitubercular antibiotic |
Autophagy (+) |
[181] |
|
Loperamide |
Anti-diarrheal |
Autophagy (+) |
[197] |
|
Nitazoxanide |
Anti-parasitic |
Autophagy (+) |
[198, 199] |
|
Pyrazinamide |
Antitubercular antibiotic |
Autophagy (+) |
[181] |
|
Streptomycin |
Aminoglycoside antibiotic |
Necrosis (-) |
[167] |