Table 1.
Baseline characteristics of PCNSL and ECNSL before PSM and after PSM.
| Variable | Before PSM (N/%) | After PSM (N/%) | ||||
|---|---|---|---|---|---|---|
| PCNSL | ECNSL | P value | PCNSL | ECNSL | P value | |
| N | 4038 (1.6%) | 246,760 (98.4%) | 4,017 (33.5%) | 7,981 (66.5%) | ||
| Age at diagnosis | 0.570 | 0.100 | ||||
| <60 | 1,651 (40.9%) | 99,799 (40.4%) | 1,637 (40.8%) | 3,128 (39.2%) | ||
| ≥60 | 2,387 (59.1%) | 146,961 (59.6%) | 2,380 (59.2%) | 4,853 (60.8%) | ||
| Sex | 0.003 | 0.784 | ||||
| Male | 2,125 (52.6%) | 135,728 (55.0%) | 2,112 (52.6%) | 4,175 (52.3%) | ||
| Female | 1,913 (47.4%) | 111,032 (45.0%) | 1,905 (47.4%) | 3,806 (47.7%) | ||
| Race | <0.001 | 0.961 | ||||
| White | 3,210 (79.5%) | 204,478 (82.9%) | 3,207 (79.8%) | 6,378 (79.9%) | ||
| Black | 345 (8.5%) | 25,581 (10.4%) | 335 (8.3%) | 654 (8.2%) | ||
| Others# | 483 (12.0%) | 16,701 (6.8%) | 475 (11.8%) | 949 (11.9%) | ||
| Marital Status | 0.006 | 0.503 | ||||
| Married | 2,357 (58.4%) | 138,678 (56.2%) | 2,351 (58.5%) | 4,620 (57.9%) | ||
| Unmarried | 1,681 (41.6%) | 108,082 (43.8%) | 1,666 (41.5%) | 3,361 (42.1%) | ||
| Histology | <0.001 | 0.849 | ||||
| DLBCL | 3,214 (79.6%) | 56,589 (22.9%) | 3,193 (79.5%) | 6,332 (79.3%) | ||
| Others$ | 824 (20.4%) | 190,171 (77.1%) | 824 (20.5%) | 1,649 (20.7%) | ||
| Chemotherapy | <0.001 | 0.506 | ||||
| Yes | 2,715 (67.2%) | 145,937 (59.1%) | 2,715 (67.6%) | 5,346 (67.0%) | ||
| No/Unknown | 1,323 (32.8%) | 100,823 (40.9%) | 1,302 (32.4%) | 2,635 (33.0%) | ||
| Radiotherapy | <0.001 | 0.234 | ||||
| Yes | 1,437 (35.6%) | 39,315 (15.9%) | 1,416 (35.3%) | 2,726 (34.2%) | ||
| No/Unknown | 2,601 (64.4%) | 207,445 (84.1%) | 2,601 (64.7%) | 5,255 (65.8%) | ||
| Surgery | <0.001 | 0.993 | ||||
| Yes | 1,734 (42.9%) | 49,024 (19.9%) | 1,718 (42.8%) | 3,414 (42.8%) | ||
| No/Unknown | 2,304 (57.1%) | 197,736 (80.1%) | 2,299 (57.2%) | 4,567 (57.2%) | ||
| Year of diagnosis | <0.001 | 0.228 | ||||
| 2000-2008 | 2,046 (50.7%) | 133,840 (54.2%) | 2,037 (50.7%) | 3,954 (49.5%) | ||
| 2009-2016 | 1,992 (49.3%) | 112,920 (45.8%) | 1,980 (49.3%) | 4,027 (50.5%) | ||
#Other races include American Indian/Alaska Native, Asian/Pacific Islander.
$Other histologies include precursor non-Hodgkin lymphoma (B-cell), chronic/small/prolymphocytic/mantle B-cell non-Hodgkin lymphoma, lymphoplasmacytic lymphoma/waldenstrom, Burkitt lymphoma/leukemia, marginal-zone lymphoma, follicular lymphoma, hairy-cell leukemia, plasma cell neoplasms, heavy chain disease, non-Hodgkin lymphoma (B-cell, not otherwise specified), non-Hodgkin lymphoma (T-cell), non-Hodgkin lymphoma (unknown lineage).
PSM, Propensity Score Matching; PCNSL, Primary Central Nerve System Lymphoma; ECNSL, Extra Central Nerve System Lymphoma; DLBCL, Diffuse Large B-Cell Lymphoma.
Bold values mean statistical significance (P < 0.05).