Table II.

First-trimester trajectories of placental development and uterine artery indices in VIRTUAL placenta subcohort for pregnancies after frozen-thawed ET (n = 32), fresh ET (n = 56), and after natural conception (n = 126).

		Model 1		Model 2
		Beta (95% CI)	P-value	Beta (95% CI)	P-value
PV ($\sqrt[3]{{\mathit{cm}}^3}$)	Frozen-thawed ET	−0.007 (−0.184, 0.170)	0.936	−0.026 (−0.206, 0.155)	0.778
	Fresh ET	Reference		Reference
	Frozen-thawed ET	0.002 (−0.160, 0.163)	0.983	0.006 (−0.162, 0.174)	0.940
	Fresh ET	0.003 (−0.127, 0.134)	0.962	0.013 (−0.132, 0.158)	0.857
	Natural conception	Reference		Reference
uPVV ($\sqrt[3]{{\mathit{cm}}^3}$)	Frozen-thawed ET	0.121(−0.098, 0.340)	0.276	0.075 (−0.147, 0.297)	0.506
	Fresh ET	Reference		Reference
	Frozen-thawed ET	0.071 (−0.121, 0.263)	0.465	0.112 (−0.085, 0.311)	0.262
	Fresh ET	−0.052 (−0.207, 0.103)	0.505	−0.009 (−0.180, 0.162)	0.916
	Natural conception	Reference		Reference
UtA-PI	Frozen-thawed ET	0.028 (−0.159 0.215)	0.767	0.023 (−0.178, 0.223)	0.833
	Fresh ET	Reference		Reference
	Frozen-thawed ET	−0.112 (−0.305, 0.080)	0.251	−0.130 (−0.330, 0.070)	0.200
	Fresh ET	−0.148 (−0.304, 0.009)	0.064	−0.125 (−0.298, 0.048)	0.155
	Natural conception	Reference		Reference
UtA-RI	Frozen-thawed ET	−0.012 (−0.039, 0.015)	0.383	−0.012 (−0.041, 0.017)	0.408
	Fresh ET	Reference		Reference
	Frozen-thawed ET	−0.022 (−0.050, 0.005)	0.112	−0.021 (−0.050, 0.007)	0.114
	Fresh ET	−0.011 (−0.034, 0.011)	0.322	−0.003 (−0.028, 0.021)	0.783
	Natural conception	Reference		Reference

ET, embryo transfer. Model 1: Adjusted for GA.

Model 2: Adjusted for GA, parity, periconceptional folic acid supplement use and smoking.