Table 2.
Comparison of the Surface Receptors Involved in Human Coronavirus Infection
| Name | Family | Receptora | Receptor-Binding Glycoproteinb | Glycosite Reported |
|---|---|---|---|---|
| HCoV-229E | Alphacoronavirus | APN | S protein | |
| HCoV-OC43 | Betacoronavirus | 9-O-acetylated sialic acid | S protein, HE protein | N133 |
| SARS-CoV | Betacoronavirus | ACE2, Heparan sulfate proteoglycans | S protein, DC-SIGN | 330NAT, 357NST, 783NFS, N158, N227 |
| HCoV-NL63 | Alphacoronavirus | ACE2, Heparan sulfate proteoglycans | S protein | Asn 358 |
| HCoV-HKU1 | Betacoronavirus | 9-O-acetylated sialic acid | S protein, HE protein | Asn171, N132, N19 |
| MERS-CoV | Betacoronavirus | DPP4, sialic acid | S protein | N155, N166, N236 |
| SARS-CoV-2 | Betacoronavirus | ACE2 | S protein | N343, N234, N165, 801NFS, 331NIT |
Notes: aAPN, aminopeptidase N; ACE2, angiotensin-converting enzyme 2; DPP4, dipeptidyl-peptidase 4. bS protein, spike protein; DC-SIGN, dendritic cell-specific intracellular adhesion molecule-3-grabbing nonintegrin; HE, hemagglutinin-esterase.