Table 5. Inputs Required to Describe the CAM^bD Problem for the Crystallization of Ibuprofen, Where Technique-Specific Constraints are Required to Describe Cooling Crystallization or Antisolvent Crystallization^a.

description	model inputs
number of solvents and API	number of solvents = 8; API = ibuprofen
candidate solvents NS (28 potential binary solvent pairs)	water, n-pentane, n-heptane, ethanol, 1-propanol, 1-butanol, 1-pentanol, acetone
temperature limits	Tmin = 293.15 K, Tmax = 318.15 K
solvent mass limits	χs ≥ 3.5 gsolvent gcrystal–1, Vs ≥ 4.0 mLsolvent gcrystal
technique-specific constraints
	ASM: T = T0

^aHere, s₁, s₂, and API refer to the solvent, the antisolvent, and ibuprofen, respectively. The operating temperatures (T₀ and T) are bounded by upper and lower limits, T_max and T_min, respectively, whilst the solvent mass is constrained only by lower limits, on a mass (χ_s) basis and on a volumetric (V_s) basis. The final (initial) moles of solvent ii in the liquid phase are represented by n_ii^L (n_ii,0). The binary variables y_s2,j express the selection of a candidate antisolvent (from the list N_S) and are included here to prevent the choice of antisolvent being a design decision in crystallization mode CP.