Table 7. Comparison of Ranked Solvent Blends for Integrated Cooling and Antisolvent Crystallization of Ibuprofen^a.

						solvents
T0/K	rank	YAPI/%	Vs/(mL/g)			s1	s2
298.15	1	99.85	7.82	1.000	0.040	ethanol	water
	2	99.84	7.90	0.603	0.027	acetone	water
	3	99.74	12.72	1.000	0.027	1-propanol	water
	4	99.61	18.72	0.556	0.020	1-butanol	water
303.15	1	99.87	6.93	1.000	0.040	ethanol	water
	2	99.87	6.57	0.580	0.027	acetone	water
	3	99.77	11.28	0.679	0.027	1-propanol	water
	4	99.70	14.65	0.497	0.020	1-butanol	water
308.15	1	99.89	5.28	0.553	0.027	acetone	water
	2	99.88	6.07	1.000	0.040	ethanol	water
	3	99.82	9.09	0.559	0.027	1-propanol	water
	4	99.77	11.07	0.486	0.020	1-butanol	water
313.15	1	99.92	4.01	0.519	0.027	acetone	water
	2	99.90	5.23	1.000	0.040	ethanol	water
	3	99.86	6.92	0.471	0.027	1-propanol	water
	4	99.84	7.92	0.467	0.020	1-butanol	water
318.15	1	99.94	4.00	0.475	0.021	acetone	water
	2	99.92	4.13	0.517	0.040	ethanol	water
	3	99.90	4.80	0.423	0.027	1-propanol	water
	4	99.88	5.78	0.438	0.020	1-butanol	water

^aIn all cases, T₀ = T_max, and the final temperature is 293.15 K. Italicized solutions are optimal mixtures with additional composition constraints, to account for the presence of LLE.