Figure 2. Juniperus communis (JCo) extract enhances the sensitivity of colorectal cancer cells to 5-fluorouracil (5-FU). HT-29 cells were treated with (A) JCo extract (0, 20, 40, 60, and 80 μg/mL) alone or JCo extract in combination with 0.25 μg/mL 5-FU or with (B) 5-FU (0, 0.125, 0.25, 0.5, and 1 μg/mL) alone or 5-FU in combination with 40 μg/mL JCo extract for 72 h. Cell viability was evaluated by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Data are reported as means±SD. *P<0.05 vs single drug in the combination group. JCo extract in combination with 5-FU displayed a synergistic effect (CI<1) (ANOVA).
