Figure 1. Engeletin protects neurons and promotes cortical vascular endothelial growth factor (VEGF) expression in vivo. A, sham group. B, middle cerebral artery occlusion (MCAO) group. C, MCAO + engeletin (20 mg/kg) group. D, MCAO+axitinib (10 mg/kg) group. E, MCAO + engeletin + axitinib group (scale bar 100 μm). Representative immunohistochemical images following engeletin treatment (20 mg/kg) and axitinib (10 mg/kg). VEGF, NeuN, and CD31 tissue positivity was quantified with the ImageJ software. Data are reported as means±SD (n=10). ^#P<0.05, ^##P<0.01 vs sham group; **P<0.01 vs MCAO group; ^△P<0.05, ^△△P<0.01 vs engeletin group (ANOVA with Tukey's test).