Figure 2. The impact of engeletin on middle cerebral artery occlusion (MCAO)-induced cerebral ischemia/reperfusion injury is mediated via VEGF/vasohibin and Ang-1/Tie-2 signaling. Rats were intragastrically administered axitinib (10 mg/kg, VEGFR-inhibitor) and injected with engeletin (20 mg/kg) following MCAO modeling. Plus and minus signs indicate that a given operation was or was not conducted. Western blotting was used to assess the expression of proteins associated with vascular stability (p-Tie2, Ang-1, and Ang-2). Data are reported as means±SD (n=10). *P<0.05, **P<0.01 vs MCAO group; ##P<0.01 vs sham group (ANOVA with Tukey's test).
