Figure 5. The impact of engeletin on middle cerebral artery occlusion (MCAO)-induced cerebral ischemia/reperfusion injury is mediated via VEGF/vasohibin (Vash) and Ang-1/Tie-2 signaling. Rats were intragastrically administered axitinib (10 mg/kg, VEGFR-inhibitor) and injected with engeletin (20 mg/kg) following middle cerebral artery occlusion (MCAO) modeling. Plus and minus signs indicate that a given operation was or was not conducted. Western blotting was used to assess the expression of proteins associated with angiogenesis (VEGF, Vash-1, and Vash-2). Data are reported as means±SD (n=10). *P<0.05, **P<0.01 vs MCAO group; ##P<0.01 vs sham group. △P<0.05, △△P<0.01 vs engeletin group (ANOVA with Tukey's test).
