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. 2021 Jul 16;54(10):e11028. doi: 10.1590/1414-431X2020e11028

Table 1. The dose-effect relationship of engeletin on cerebral ischemia/reperfusion injury in rats.

Group Survival rate(%) Infarct volume(%) Brain water content(%) Neurological function (score)
Sham 100 - 76.1±0.5 -
MCAO 66.66 22.3±5.7 78.1±0.5## 9.4±1.5
Engeletin, 10 mg/kg 75 20.1±5.4 77.4±0.4 7.7±1.5*
Engeletin, 20 mg/kg 75 18.3±4.7* 77.3±0.4* 7.4±1.6**
Engeletin, 40 mg/kg 88.33 17.2±4.1** 77.0±0.5** 7.2±1.7**

Data are reported as means±SD (n=12/group). *P<0.05, **P<0.01 vs middle cerebral artery occlusion (MCAO) group; ##P<0.01 vs sham group (ANOVA with Tukey's test).