Table 1. The dose-effect relationship of engeletin on cerebral ischemia/reperfusion injury in rats.
Group | Survival rate(%) | Infarct volume(%) | Brain water content(%) | Neurological function (score) |
---|---|---|---|---|
Sham | 100 | - | 76.1±0.5 | - |
MCAO | 66.66 | 22.3±5.7 | 78.1±0.5## | 9.4±1.5 |
Engeletin, 10 mg/kg | 75 | 20.1±5.4 | 77.4±0.4 | 7.7±1.5* |
Engeletin, 20 mg/kg | 75 | 18.3±4.7* | 77.3±0.4* | 7.4±1.6** |
Engeletin, 40 mg/kg | 88.33 | 17.2±4.1** | 77.0±0.5** | 7.2±1.7** |
Data are reported as means±SD (n=12/group). *P<0.05, **P<0.01 vs middle cerebral artery occlusion (MCAO) group; ##P<0.01 vs sham group (ANOVA with Tukey's test).