Table 2. The impact of engeletin on mean cerebral blood flow in cerebral ischemia/reperfusion model rats.
Group | Before MCAO | MCAO (0 h) | 72 h | 168 h |
---|---|---|---|---|
Sham | 1123.5±150.7 | 1033.6±134.5 | 1145.6±169.3 | 1131.8±201.3 |
Model | 1131.9±127.9 | 505.6±88.4** | 870.5±325.8** | 820.4±213.4** |
Engeletin, 20 mg/kg | 1128.6±122.6 | 523.66±94.2** | 1040.7±342.1## | 950.4±265.1## |
Axitinib, 10 mg/kg | 1178.6±164.6 | 513.45±85.7** | 733.6±257.4** | 785.4±112.3** |
Axitinib, 10 mg/kg + engeletin 20 mg/kg | 1149.3±167.4 | 510.48±92.5** | 893.6±311.6* | 860.5±133.2* |
Data are reported as means±SD (n=10/group). *P<0.05, **P<0.01 vs sham group; ##P<0.01 vs Model group (ANOVA with Tukey's test).