Table 1. Demographics and characteristics.
Values are reported in the given units with standard deviation in parentheses, and all comparisons between groups were non-significant. Recipients are both adult (>18 years) and pediatric (≤ 18 years) in each cohort. Clinical pathology data are based on the day of biopsy, which is timed with the urine collection, which occurred before performance of the biopsy. ABMR/TCMR split is of AR-confirmed patients, based on the Banff allograft pathology classification (17). All other demographic and clinical information is based on the day of the kidney transplant.
| Phenotype Characteristic | Training (n = 111) | Validation #1 (n = 103) | Validation #2 (n = 59) |
|---|---|---|---|
| Recipient | |||
| • Recipient age, year (SD) | 29 (13.4) | 32 (14.2) | 32 (11.7) |
| • Recipient male/female, % | 48/52 | 49/51 | 42/58 |
| Donor | |||
| • Donor age, year (SD) | 35 (12.4) | 36 (14.4) | 39 (10.0) |
| • Donor male/female, % | 43/57 | 44/56 | 40/69 |
| Ethnicity, % | |||
| • Caucasian | 35 | 39 | 48 |
| • Hispanic | 32 | 25 | 21 |
| • Asian | 26 | 27 | 24 |
| • African American | 3 | 2 | 2 |
| • Other | 4 | 7 | 5 |
| Donor Source, % | |||
| • Deceased | 49.4 | 42.4 | 55% |
| Clinical Pathology | |||
| • AR / STA | 39/72 | 32/71 | 32/27 |
| • ABMR/TCMR (of AR) | 24/15 | 9/23 | 5/27 |
| Cause of ESRD, % | |||
| • Obstructive | 5 | 4 | 5 |
| • Diabetes | 20 | 22 | 18 |
| • Hypertension | 43 | 37 | 42 |
| • Glomerulonephritis | 8 | 7 | 7 |
| • Immune-Mediated | 20 | 23 | 24 |
| • Congenital | 5 | 4 | 2 |
| • Other | 1 | 5 | 2 |