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NO-cGMP pathway showing paracrine effect of endothelial NO on vascular smooth muscle cell. NO, nitric oxide; NOS, nitric oxide synthase; BH4, tetrahydrobiopterin; sGC, soluble guanylate cyclase; GTP, guanosine triphosphate; cGMP, cyclic guanosine monophsphate; PDE, phosphodiesterase; PDE5i, PDE5 inhibitor; PKG, protein kinase G; MYTP, myosin phsophatase targeting subunit; MLCK, myosin light chain kinase; ROCK, Rho kinase.
