Table 2. Presenting characteristics of patients with sinonasal osteosarcoma included in the systematic review.
| Demographics | Mean (SD) | Patients n = 88 (%) |
|---|---|---|
| Age (y) | 38.5 (21.7) | |
| Sex | ||
| Male | 37/78 (47.4) | |
| Female | 41/78 (52.5) | |
| Presenting symptoms | ||
| Facial mass/swelling | 17/51 (33.3) | |
| Nasal obstruction | 16/51 (31.3) | |
| Headache | 12/51 (23.5) | |
| Epistaxis | 10/51 (19.6) | |
| Oral mass/swelling | 8/51 (15.7) | |
| Facial pain | 8/51 (15.7) | |
| Proptosis | 7/51 (13.7) | |
| Epiphoria | 6/51 (11.8) | |
| V2 hypesthesia/parasthesias | 6/51 (11.8) | |
| Past history | ||
| History of prior radiation therapy | 24/69 (34.7) | |
| Dose (Gy) | 57.2 (7.7) | |
| Duration prior to osteosarcoma (y) | 12.9 (8.4) | |
| Paget's disease | 1/40 (2.5) | |
| Retinoblastoma | 5/48 (7.2) | |
| Location of osteosarcoma involvement a | ||
| Maxillary sinus | 46/72 (63.8) | |
| Ethmoid sinus | 39/75 (52.0) | |
| Nasal cavity | 34/74 (45.9) | |
| Sphenoid sinus | 19/68 (27.9) | |
| Frontal sinus | 13/66 (19.7) | |
| Pathologic analysis | ||
| Histologic type b | ||
| Osteoblastic | 40/53 (75.4) | |
| Chondroblastic | 17/53 (31.5) | |
| Fibroblastic | 11/53 (20.4) | |
| Grade | ||
| High grade | 21/34 (61.7) | |
| Low grade | 13/34 (38.2) | |
| AJCC T stage | ||
| T1–T3 | 29/71 (40.8) | |
| T4 c | 42/71 (59.1) | |
| Invasion of orbit | 23/71 (32.4) | |
| Invasion of dura | 13/71(18.3) | |
| Invasion of pterygoid muscles | 8/71 (11.4) | |
| Invasion of infratemporal fossa | 7/71(10.0) | |
| Invasion of nasopharynx | 5/71 (7.1) | |
| Invasion of clivus | 4/71 (5.7) | |
| Invasion of skin | 3/71 (4.2) | |
Abbreviation: AJCC, American Joint Committee on Cancer; SD, standard deviation; T, tumor.
a
Tumor may involve multiple sites.
b
A portion of tumors contained multiple histologic types.
c
Several tumors had invasion into numerous structures.