Table 3.
Effect of Hashimoto's disease on cytokine levels in saliva and plasma. IL: 1α, 1β, 1RA, 2, 2RA, 3,4, 5,6,7,8,9, 10, 12 (p40), 12 (p70), 13, 15, 16, 17, 18-interleukin: 1α, 1β, 1RA, 2, 2RA, 3,4, 5,6,7,8,9, 10, 12 (p40), 12 (p70), 13, 15, 16, 17, 18; IFN-γ: interferon-γ; IFN-α2: interferon-α2; TNF-α, β: tumor necrosis factor α, β; HGF: hepatocyte growth factor; MIF: macrophage migration inhibitory facto;, ND: no detectable.
| Saliva | Plasma | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Control group | Study group | p value | Control group | Study group | p value | |||||
| Mean ± SD | Median (min-max) | Mean ± SD | Median (min-max) | Mean ± SD | Median (min-max) | Mean ± SD | Median (min-max) | |||
| IL-3 | 35.11 ± 11.41 | 38.88 (7-56) | 47.33 ± 17.3 | 45 (13-80) | 0.0074 | 26.72 ± 4.009 | 27.47 (19.79-35.24) | 36.28 ± 9.588 | 36.01 (19.1-58.72) | <0.0001 |
| IFN-γ | 25.12 ± 8.914 | 23.57 (12.23-54.5) | 46.5 ± 15.09 | 43.54 (19.11-81.46) | <0.0001 | 164.4 ± 50.86 | 169.5 (43.5-236) | 235.9 ± 69.13 | 233.2 (123-427.9) | 0.0001 |
| IL-5 | 6.065 ± 1.85 | 6.05 (0.6-9.4) | 8.49 ± 3.975 | 8.6 (1.2-15.65) | 0.015 | 106.4 ± 75.49 | 94.43 (7.968-320.2) | 160.3 ± 67.12 | 158.5 (41.24-301.3) | 0.003 |
| IL-6 | 72.01 ± 27.06 | 73.59 (19-136) | 110.8 ± 69.45 | 103 (17-297) | 0.0187 | 3.065 ± 0.6913 | 3.147 (1.568-4.517) | 5.051 ± 2.172 | 5.202 (0.7955-9.66) | 0.0002 |
| TN-α | 8.173 ± 5.213 | 6.975 (0.625-21.68) | 15.79 ± 8.211 | 15.15 (1.28-37.39) | 0.0003 | 12.5 ± 5.202 | 12.63 (6.019-27.13) | 22.32 ± 8.808 | 21.27 (6.815-38.84) | <0.0001 |
| IL-12 (p40) | 12.45 ± 4.186 | 12 (6.614-21.75) | 19.5 ± 5.242 | 19.5 (8.004-29.9) | <0.0001 | 13.61 ± 3.629 | 13.81 (8.131-21.28) | 17.41 ± 6.56 | 17.59 (6.718-33.75) | 0.0211 |
| HGF | 3.908 ± 0.9919 | 3.842 (1.599-6.273) | 5.412 ± 1.614 | 5.373 (3.063-8.694) | 0.0012 | 60.7 ± 6.446 | 60.69 (43.81-74.71) | 77.82 ± 9.324 | 75.83 (66.35-103.7) | <0.0001 |
| IL-1α | 760.6 ± 360.9 | 766.1 (189.2-1375) | 1054 ± 441.2 | 1148 (408.2-2182) | 0.0223 | 328 ± 227.5 | 271 (15-970) | 458.5 ± 346 | 417.5 (39.38-1619) | 0.0741 |
| IL-1β | 99.04 ± 65.47 | 74.05 (22.53-245.4) | 153.2 ± 86.18 | 153.3 (28.93-343.5) | 0.0223 | 17.54 ± 9.707 | 17.28 (1.302-33.61) | 24.46 ± 8.32 | 24.38 (8.663-48.13) | 0.017 |
| IL-1RA | 5170 ± 1847 | 5071 (917-7936) | 6951 ± 2239 | 6707 (3196-10575) | 0.0071 | 13.49 ± 7.875 | 12.01 (0.7689-31.98) | 19.32 ± 8.643 | 17.87 (4.071-40.51) | 0.02 |
| IL-8 | 1564 ± 913.3 | 1479 (87.75-3855) | 1230 ± 1167 | 882 (21-5426) | 0.0429 | 24.43 ± 8.201 | 25.36 (6.595-38.56) | 9.871 ± 7.801 | 7.724 (-5.24-27.19) | <0.0001 |
| IL-10 | 28.49 ± 10.39 | 26.5 (10.22-47) | 19.69 ± 9.166 | 19 (2.235-40.22) | 0.0049 | 34.42 ± 9.252 | 35.14 (13.04-49.94) | 23.61 ± 11.09 | 21.76 (4.953-47.42) | 0.0004 |
| IL-2 | 27.58 ± 10.46 | 30 (4-46) | 30.23 ± 12.54 | 29 (9.218-58) | 0.6685 | 116.7 ± 48.75 | 129.7 (18.51-189.3) | 140.9 ± 64.07 | 144.7 (25.42-298.6) | 0.1213 |
| IL-2RA | 39.98 ± 20.56 | 37.13 (3.823-86.66) | 40.09 ± 20.86 | 39 (2.598-87) | 0.9578 | 28.35 ± 3.504 | 27.91 (22.57-34.75) | 30.79 ± 5.045 | 32.49 (19.24-37.89) | 0.0389 |
| IL-4 | 16.22 ± 7.095 | 15 (2-33.5) | 19.85 ± 7.338 | 18 (9-36) | 0.0625 | 23.97 ± 4.79 | 24.39 (15.87-31.69) | 26.25 ± 11.21 | 26.8 (1.017-47.67) | 0.3067 |
| IL-7 | 17.91 ± 4.275 | 18 (9.391-25) | 17.8 ± 8.887 | 16.5 (4.807-42) | 0.455 | 5.099 ± 2.223 | 4.495 (1.972-10.08) | 7.364 ± 4.663 | 6.964 (0.6749-17.65) | 0.1035 |
| IL-9 | 45.98 ± 17.78 | 47 (16.48-82) | 53.85 ± 21.96 | 55 (12.07-99) | 0.1806 | 49.19 ± 20.28 | 48.04 (21.43-91.61) | 55.94 ± 25.79 | 58.96 (8.061-92.59) | 0.2799 |
| IL-12 (p70) | 22.59 ± 8.404 | 22.79 (3.101-36.6) | 25.25 ± 7.734 | 24 (9.988-36.5) | 0.2907 | 16.17 ± 6.58 | 16.96 (3.493-30.17) | 24.02 ± 11.11 | 20.41 (2.664-44.17) | 0.0102 |
| IL-13 | 1.013 ± 0.4813 | 1.027 (0.3138-1.833) | 1.287 ± 0.7352 | 1.137 (0.1965-2.41) | 0.2022 | 9.829 ± 4.507 | 9 (3.549-21.14) | 12.41 ± 3.768 | 12 (5.41-22) | 0.0161 |
| IL-15 | 10.72 ± 5.484 | 10.2 (0.473-23) | 12.35 ± 9.511 | 9.6 (2.85-35.3) | 0.7619 | ND | ND | ND | ND | ND |
| IL-16 | 981.3 ± 515.6 | 941.6 (80.27-2125) | 1095 ± 594.9 | 1012 (235.8-2163) | 0.5253 | 161.6 ± 127.1 | 129 (11.15-587) | 175.3 ± 165.5 | 141.5 (5.34-780) | >0.9999 |
| IL-17 | ND | ND | ND | ND | ND | 33.74 ± 11.03 | 29.5 (21.41-58) | 27.58 ± 12.11 | 26.6 (8.334-56.7) | 0.0466 |
| IL-18 | 369.3 ± 379.1 | 331.5 (10.73-1999) | 399.7 ± 403.2 | 280 (4.705-1829) | 0.9847 | 20.7 ± 9.127 | 22.17 (3.895-33.62) | 23.2 ± 14.99 | 21.47 (2.131-57.12) | 0.6581 |
| IFN-α2 | 4.61 ± 0.9551 | 4.539 (2.918-7.328) | 5.053 ± 1.844 | 5.054 (1.601-10.47) | 0.3859 | 22.81 ± 6.25 | 22.29 (9.482-34.99) | 22.71 ± 7.463 | 21.31 (2.789-39.93) | 0.8777 |
| MIF | 759.7 ± 323.3 | 661 (258.2-1424) | 750.5 ± 538.5 | 601 (119.5-2221) | 0.4185 | 196.5 ± 78.99 | 208 (44.66-340.8) | 206.2 ± 79.61 | 184.4 (81.59-359.2) | 0.8929 |
| TNF-β | 5.702 ± 1.994 | 5.986 (0.7912-9.791) | 7.135 ± 2.727 | 7.033 (1.758-11.87) | 0.0925 | 6.692 ± 2.137 | 6.997 (1.33-10.08) | 9.793 ± 4.96 | 10.01 (-2.785-17.23) | 0.0028 |