Table 2.
Light microscopy histological lesions.
| Total (N = 71) | IgAN (N = 28) | FSGS (N = 22) | MGN (N = 21) | p value | ||
|---|---|---|---|---|---|---|
| Total glomeruli | 20 ± 11 | 21 ± 10 | 21 ± 13 | 18 ± 8 | ns | |
| Patients with segmental sclerosis (%) | 66 | 61 | 100 | 29 | <0.001 | |
| Percentage of segmentally sclerosed glomeruli over total glomeruli | 10 ± 10 | 10 ± 9a,b | 16 ± 9a,c | 3 ± 5b,c | a: 0.012 b: 0.003 c: <0.001 |
|
| Patients with global glomerulosclerosis (%) | 82 | 89 | 86 | 67 | ns | |
| Percentage of globally sclerosed glomeruli over total glomeruli | 24 ± 21 | 26 ± 21 | 33 ± 24α | 13 ± 13α | α: <0.001 | |
|
| ||||||
| Interstitial fibrosis-tubular atrophy (%) | <25 | 52 | 50 | 41 | 67 | ns |
| ≥25–<50 | 38 | 43 | 36 | 33 | ns | |
| ≥50 | 10 | 7 | 23 | 0 | ns | |
|
| ||||||
| Interstitial inflammation (%) | Absent | 30 | 25 | 23 | 43 | ns |
| Sparse | 27 | 25 | 32 | 24 | ns | |
| Dense | 44 | 50 | 45 | 33 | ns | |
|
| ||||||
| Patients with interstitial inflammation inside fibrotic areas (%) | 61 | 61 | 73 | 48 | ns | |
| Patients with arteriolar hyalinosis (%) | 61 | 75 | 55 | 48 | ns | |
| Patients with crescents (%) | 8 | 21 | 0 | 0 | 0.004 | |
| Percentage of glomeruli with crescents over total glomeruli | 1 ± 4 | 3 ± 7 | 0 | 0 | 0.028 | |
Note. Data are presented as mean value ± standard deviation or as percentage. FSGS: focal segmental glomerulosclerosis, IgAN: IgA nephropathy, MGN: membranous glomerulopathy, and ns: not significant.