Table 1.

Effect of resveratrol on life extension.

Study type	Subjects	Administration methods	Dose & duration	Main effects	Ref.
In vitro, in vivo	Human cells, Caenorhabditis elegans	Culture	100 μM	Induced autophagy in human cells and Caenorhabditis elegans, prolonged lifespan in Caenorhabditis elegans through the Sirt1-dependent induction of autophagy	[23]
In vivo	Honey bees	Administered in candy and syrup	10 ppm	Inhibited Nosema ceranae infection and prolonged lifespan of honey bees	[24]
In vivo	Drosophila melanogaster	Diet supplement	25-800 μM	Extended adult longevity in both the male and female flies by scavenging ROS and neuroprotection	[25]
In vivo	Rats	Diet supplement	NA	Delayed vascular aging, but did not extend lifespan	[29]
In vivo	Nothobranchius guentheri (fish)	Diet supplement	200 μg/g food	Prolonged longevity, improved cognitive ability and aging-related histological markers	[27]
In vivo	Drosophila melanogaster	Culture	NA	Prolonged longevity, ameliorated age-related symptoms	[26]
In vivo	HtrA2 knockout mice	Oral administration	25 mg/kg BW	Prolonged longevity, delayed worsening of the motor phenotype	[28]

Note: NA: not available; ROS: reactive oxygen species; BW: body weight.