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. 2021 Jul 20;36(5):109493. doi: 10.1016/j.celrep.2021.109493

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© 2021 The Authors

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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Lung histopathology of vaccinated Syrian hamsters on days 2–14 after challenge

(A–F) Histopathological evaluation and scoring of lung pathology. Parameters assessed: estimated percentages of affected lung areas (A), degree of bronchitis (B), lung inflammation (C), endothelialitis (D), edema (E), and epithelial hyperplasia (F). Scores and parameters in (B)–(F) were classified as absent (0), minimal (1), mild (2), moderate (3), or severe (4). n = 3 for each treatment at each time point.

(G–V) Representative photomicrographs of formalin-fixed, paraffin-embedded, hematoxylin and eosin-stained lung tissues: bronchial epithelium (G)–(J), air spaces (K)–(V). Insets in (G)–(J) show the distribution of SARS-CoV-2 RNA, visualized by in situ hybridization in lungs of Syrian hamsters on day 2 after challenge. Red signal: viral RNA; blue: hemalaun counterstain. Insets in (O)–(R) show blood vessels affected by endothelialitis on day 5 after challenge. Pathological changes are shown from representative animals that had been either mock-vaccinated (Mock) or vaccinated with CPD6, sCPD9, or sCPD10. Bars: 50 μm (G–V), 1 mm (insets G–J), 100 μm (insets O–R).