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. 2021 Jul 20;16(9):2274–2288. doi: 10.1016/j.stemcr.2021.07.012

Figure 5.

Figure 5

Pro-inflammatory macrophages are enriched in hearts of SARS-CoV-2-infected hamsters

(A) Relative expression levels of Ccl2 in LA, LV, and RA heart tissues obtained from SARS-CoV-2-infected hamsters (n = 3) and mock-infected hamsters (n = 3).

(B and C) Immunofluorescence staining (B) and quantification (C) of Ccl2 in LA, LV, and RA heart tissues obtained from SARS-CoV-2-infected hamsters (n = 3) and mock-infected hamsters (n = 3). Scale bar, 50 μm.

(D) Cell-mixture deconvolution identified the enrichment of immune cells in the LA, LV, and RA of SARS-CoV-2-infected hamsters (n = 3) compared with mock-infected hamsters (n = 3).

(E and F) Immunohistochemistry staining (E) and quantification (F) of CD163+ cells in LA, LV, and RA heart tissues obtained from SARS-CoV-2-infected hamsters (n = 3) and mock-infected hamsters (n = 3). Scale bar, 50 μm.

Data are presented as mean ± SD. p values were calculated by unpaired two-tailed Student’s t test. ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001.