Table 1.
Key Findings From Studies Examining Cerebellar Structural Alterations in Psychotic Disorders
| Year, Reference | n | Main Cerebellar Finding(s) |
|---|---|---|
| 1979 (96) | 70 patients with SZ | Pronounced atrophy of the cerebellar vermis in ~17% of patients with SZ |
| 1994 (166) | 52 patients with SZ, 90 HC subjects | No group differences in total cerebellar volume between patients with SZ and HC subjects |
| 1994 (167) | 36 patients with SZ, 52 HC subjects | No group differences in vermal volumes between patients with SZ and HC subjects |
| 2010 (168) | 54 patients with SZ, 100 HC subjects | Reduced gray matter volume in bilateral anterior cerebellum |
| 2012 (103) | 29 patients with SZ, 45 HC subjects | Reduced volume of left cerebellar crus I and II in patients with SZ |
| 2015 (169) | 32 patients with SZ, 52 HC subjects | Reduced total cerebellar volume in patients with SZ |
| 2015 (170) | 784 patients with SZ, 936 HC subjects | Patterns of both reduced and increased cerebellar gray matter concentration in patients with SZ |
| 2017 (171) | 37 patients with SZ, 62 HC subjects | Reduced volume of bilateral cerebellar crus I and II in patients with SZ |
| 2018 (104) | 158 patients with SZ, 88 HC subjects | Reduced volume of bilateral cerebellar lobules VIII and VI/crus I in patients with SZ |
| 2018 (101) | 983 patients with SZ, 1349 HC subjects | Reduced total and regional cerebellar volumes in patients with SZ, with most prominent effects in “cognitive” cerebellar regions (e.g., crus I/II) |
| 2018 (105) | 218 patients with SZ, 190 patients with BD, 256 HC subjects | Pronounced cerebellar volume reductions in a small subset of patients with SZ and patients with BD, but large within-group variability |
| 2019 (106) | 417 patients with SZ, 389 HC subjects | Reduced cerebellar gray matter volume (vermal lobules IV–V and left crus I) in first-episode, drug-naïve patients with SZ (meta-analysis) |
| 2019 (102) | 1401 HC subjects | Level of (primarily subclinical) psychotic symptoms were associated with cerebellar volume (VI/crus I) in a community adolescent sample |
BD, bipolar disorder; HC, healthy control; SZ, schizophrenia.