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. Author manuscript; available in PMC: 2022 Aug 1.
Published in final edited form as: Mol Genet Metab. 2021 Jun 24;133(4):386–396. doi: 10.1016/j.ymgme.2021.06.008

Table 3:

Percent change, p-values, and 95% confidence intervals for ANCOVA group comparisons. Mean cerebellar metabolic values with standard deviations are also reported. LOTS patients drove most of the significant metabolic differences. All p-values are un-adjusted but are corrected for multiple comparisons and noted in bold.

Cerebellum
Metabolic Values
NAA mI Glx Cr Cho
% Change p-values [95% CI]
10 LOGG vs. 7 CTRL −20.0%
0.015
[0.3657, 2.4934]
26.7%
0.043
[0.1005, 3.0279]
−16.9%
0.065
[−0.0570, 4.2779]
−5.6%
0.14
[−0.1778, 1.1582]
−5.8%
0.071
[−0.0064, 0.2423]
7 LOTS vs. 7 CTRL −28.2%
0.0003*
[1.093, 2.923]
38.7%
0.0064*
[0.8773, 3.6513]
−25.6%
0.0018*
[1.4071, 4.9871]
−10.0%
0.0065*
[0.3354, 1.4062]
−6.3%
0.12
[−0.0257, 0.2759]
Concentration (mean± SD)
LOGG Patients 5.71±1.24 7.40±1.67 10.41±2.59 8.20±0.71 1.96±0.10
LOTS Patients 5.13±0.99 8.10±1.48 9.32±2.04 7.82±0.41 1.95±0.12
LOSD Patients 7.06±0.26 5.77±0.58 12.94±2.00 9.09±0.27 1.98±0.07
Controls 7.14±0.50 5.84±0.81 12.52±0.74 8.69±0.51 2.08±0.14
*

Denotes regions significant after FDR multiple comparisons corrections