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. 2021 Feb 2;70(8):2353–2365. doi: 10.1007/s00262-021-02859-x

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Increased expression of CD30 and OX40 by circulating CD45RO⁺ Tregs from CRC patients. a Representative dot plots and histograms of CD30 and OX40 expression on CD45RA⁻CD45RO⁺ Tregs from healthy subjects (n = 14) and CRC patients (n = 25) are shown. Numbers within plots represent percentages. Gates for dot plots were drawn based on isotype control antibodies. White-filled histogram: isotype control antibody; gray-filled histogram: antigen-specific antibody. b, d Proportions of circulating OX40⁺ Tregs and corresponding MFI in healthy subjects and CRC patients. c, e Proportions of circulating CD30⁺ Tregs and corresponding MFI in healthy subjects and CRC patients. f Proportions of circulating CD4⁺CD25⁺CD127⁻ Tregs in healthy subjects and CRC patients. Means ± SD are shown. Statistical analyses in b–f were performed using the two-tailed unpaired t test with Welch’s correction. *, **, and **** denote P < 0.05, P < 0.01, and P < 0.0001, respectively