Table 3.

Significant neuropsychiatric and demographic contributors to domains of caregiver burden

Outcome	Predictors	Standardized β coefficient	p value	β coefficient	95% CI	Adjusted R2
CBI total score	Agitation severity	0.180	< 0.001	3.893	2.0, 5.786	0.399
	Anxiety severity	0.170	< 0.001	3.472	1.793, 5.151
	Apathy severity	0.168	< 0.001	2.875	1.405, 4.345
	Nighttime behaviors severity	0.118	0.005	1.957	0.581, 3.333
	Hallucinations severity	0.109	0.025	2.531	0.318, 4.744
	Depression severity	0.086	0.049	1.568	0.007, 3.129
Time dependency	Anxiety severity	0.224	< 0.001	1.407	0.886, 1.928	0.385
	Hallucinations severity	0.172	< 0.001	1.228	0.540, 1.916
	Female sex	− 0.133	0.001	− 1.642	− 2.591, − 0.693
	Apathy severity	0.124	0.005	0.650	0.194, 1.106
	Duration of caregiving	0.114	0.004	0.110	0.035, 0.185
	Nighttime behaviors severity	0.098	0.022	0.500	0.073, 0.927
	Age	0.088	0.027	0.046	0.005, 0.087
Development	Apathy severity	0.217	< 0.001	1.120	0.660, 1.580	0.357
	Anxiety severity	0.169	< 0.001	1.047	0.522, 1.572
	Nighttime behaviors severity	0.145	0.001	0.730	0.300, 1.160
	Agitation severity	0.123	0.008	0.802	0.208, 1.396
	Hallucinations severity	0.101	0.044	0.711	0.019, 1.403
Physical	Nighttime behaviors severity	0.147	0.002	0.507	0.194, 0.820	0.275
	Anxiety severity	0.133	0.004	0.564	0.181, 0.947
	Depression severity	0.131	0.006	0.497	0.141, 0.853
	Apathy severity	0.112	0.021	0.396	0.062, 0.730
	Agitation severity	0.096	0.05	0.432	0.002, 0.862
Emotional	Disinhibition severity	0.218	< 0.001	1.201	0.641, 1.761	0.210
	Agitation severity	0.199	< 0.001	0.873	0.431, 1.315
	Female sex	0.104	0.019	0.854	0.141, 1.567
Social	Agitation severity	0.253	< 0.001	1.205	0.727, 1.683	0.212
	Age	− 0.193	< 0.001	− 0.072	− 0.105, − 0.039
	Apathy severity	0.103	0.04	0.389	0.018, 0.760

Six individual regression models were run, one for each respective CBI component, each containing all NPI severity items, age, sex, and caregiving duration. Full model shown in supplementary material