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. 2021 Jul 19;11:14713. doi: 10.1038/s41598-021-94321-2

Table 2.

Biomarker levels.

CD (n = 65*) UC (n = 107*) IBS (n = 18*) HS (n = 20*) p-value
C6Ma3 (ng/mL) [range]

2.150 [1.022–5.314]

n = 59

2.2 [0.806–5.030]

n = 100

2.07 [0.708–3.93]

n = 18

3.178 [1.672–9.314]

n = 16

CD vs. UC: > 0.9999
CD vs. IBS: > 0.9999
CD vs. HS: 0.0122
UC vs. IBS: > 0.9999
UC vs. HS: 0.0102
IBS vs. HS: 0.0326
PRO-C6 (ng/mL) [range]

7.012 [3.632–23-5]

n = 65

6.811 [3.902–19.43]

n = 106

6.59 [4.28–32.83]

n = 18

7.00 [5.264–17.45]

n = 20

CD vs. UC: > 0.9999
CD vs. IBS: > 0.9999
CD vs. HS: > 0.9999
UC vs. IBS: > 0.9999
UC vs. HS: > 0.9999
IBS vs. HS: > 0.9999
CRP(mg/L) [range]

2.35 [0.3–45]

n = 64

2.5 [0.4–91]

n = 107

1.55 [0.6–16]

n = 18

1.0 [0.6–24]

n = 19

CD vs. UC: > 0.9999
CD vs. IBS: 0.3365
CD vs. HS: 0.1174
UC vs. IBS: 0.7164
UC vs. HS: 0.2756
IBS vs. HS: > 0.9999
FC (μg/g) [range]

127 [5–4624]

n = 58

141 [5–6000]

n = 100

15 [5–69]

n = 18

CD vs. UC: > 0.9999
CD vs. IBS: < 0.0001
CD vs. HS: n.a.
UC vs. IBS: < 0.0001
UC vs. HS: n.a.
IBS vs. HS: n.a.

Median values with ranges.

*Changes in sample size due to missing values for the specific biochemical markers. The samples size for each biomarker is stated in the table. Differences in biomarker levels were investigated with Kruskal–Wallis. p-values adjusted with Dunn’s multiple comparisons test are presented in the table. Statistical significance was defined as p < 0.05.